RE: Across Pennsylvania
If you are in the Bloomsburg area, May's Barbecue has good (but not Southern-like) sandwiches. Jimmy's Quick Lunch has good cheap hot dogs in downtown Hazleton. It's an institution as is Senape's Bakery for addictive "pitza" (cold pizza) in Hazleton. Everybody's Cafe is a cute place just west of downtown Stroudsburg---excellent tapas, etc.
The Stern's have written about Plyler's (Brookville-western PA) good pizza with funky toppings, though I haven't been there in years. Closer to the 81 split are the also Roadfood approved Tom's Kitchen (Conyngham) for good blue plate meals and the Family Diner in White Haven (excellent pancakes/scrapple) for breakfast.