Re:Barbeque in Charleston SC
Totally depends on what kind of barbeque/sauce you prefer. I assume you're talking about pulled pork.
For my money, the best is JB's Smoke Shack on Johns Island; more of a tomato/vinegar hybrid sauce, and pretty good veggies too.
If you like the mustard sauce, the Bessinger brothers have a couple of places; Bessinger's on Savannah Highway has a buffet that's only open Thursday through Sunday, but it has a slightly more "mass-produced" feel. Melvin's is owned by his brother and has locations in Mt. P and James Island, very similar to Bessinger's but just a sandwich shop.
Finally, if you like the pure vinegar sauce, Mama Brown's in Mount Pleasant (almost all the way to Sullivans) is the best, and has the best sides out of all of them.
Enjoy your trip...