Littleman is almost invariably right on many things, but I can't back him on a detour that vast to Augusta for anything, least of all Sconyers, whose heyday was during the Carter presidency.
In Brunswick (more accurately Darien), I have wanted to try B&J Steaks and Seafood for a while (http://www.urbanspoon.com...-Steaks-Seafood-Darien
), and, of course, there's the awesome Willie's Wee-Nee Wagon, whose pork chop sandwich is probably not bettered anywhere.
I might also think about swinging by the Kingsman, in Cayce, a suburb of Columbia, for a pimento cheeseburger. I-77 is a really ugly bore between Columbia and Rock Hill, so have some good tunes ready to distract you! Just before Rock Hill, along SC-9 about ten miles east, there's a southern cooking place called Wagon Wheel that I've heard good things about. Then of course there are Bill Spoon's and Bar-B-Q King in Charlotte.
Charleston's not a bad town. Taylor Books is one of my favorite in the country.