Off the top of my head:
In Lake Placid in addition to the aforementioned recommended Caribbean Cowboy, check out Woody's http://www.seriouseats.com/2010/08/hot-dog-of-the-week-woodys-brats-hots-lake-placid-ny.html
I found it last fall just as she was closing. She offered to make me something but I declined, seeing she just finished cleaning. Nicola's on Main makes a good pizza. Saranac Sourdough is one of my favorites for breakfast. Coff E Bean for coffee, espresso and a great view of Mirror Lake. The Cottage at Mirror Lake Inn. Lake Placid Brewing- Great beer, good food. (I like it much better than Great Adirondack, which is ok for people watching.)
In Saranac Lake- Blue Moon Cafe. The Left Bank Cafe had just opened and was seasonal so I don't know how they are doing right now. But it is a great location on the river in town.
Inlet- Tamarac Cafe. There's a bakery across the street that is very good as well.
Long Lake- Long Lake Diner and the Adirondack Hotel. Ice cream on the corner.
Warrensburg- Oscar's Smokehouse is not to be missed. Burned down last year and reopened.
In Old Forge, around the corner from the hardware store on a side street is a tiny bakery with great donuts and bread.
Raquette Lake- the tavern behind the general store is still old time Adirondacks.
<message edited by RC51Mike on Sat, 04/30/11 4:00 PM>