Taken off Wikipedia.
"There have been repeated attempts to turn the book into a film. In 1982, Harold Ramis was to write and direct an adaptation starring John Belushi and Richard Pryor, but Belushi's death would prevent this. Later, John Candy and Chris Farley would be touted for the lead, leading many to ascribe a curse to the role.
A version adapted by Steven Soderbergh and Scott Kramer, and slated to be directed by David Gordon Green, was scheduled for release in 2005. The film was to star Will Ferrell as Ignatius and Lily Tomlin as Ignatius's mother. A staged reading of the script took place at the 8th Nantucket Film Festival, with Ferrell as Ignatius, Anne Meara as his mother, Paul Rudd as Officer Mancuso, Kristen Johnston as Lana Lee, Mos Def as Burma Jones, Rosie Perez as Darlene, Olympia Dukakis as Santa Battaglia and Miss Trixie, Natasha Lyonne as Myrna, Alan Cumming as Dorian Green, John Shea as Gonzales, Jesse Eisenberg as George, John Conlon as Mr. Claude Robichaux, Jace Alexander as Bartender Ben, Celia Weston as Miss Annie, Miss Inez & Mrs. Levy, and Dan Hedaya as Mr. Levy. However, due to difficulties pertaining to the publisher's rights, the film never actually began production.[5]
British performer and writer Stephen Fry was at one point commissioned to adapt Toole's book for the screen.[6]"