Re:The funniest Comic Strip of all time
My current favorite strip is Richard Thompson's "Cul de Sac". If you look for it currently though, it's not his work - he's been going through a treatment regimen for Parkinson's, and in a nice case of comic-artist solidarity, several others are standing in doing his strip in one-week stints. Michael Jantze (The Norm) just finished a run, and in the lineup is Stephen Pastis (Pearls Before Swine).
Now "Mark Trail" has been (unintentionally) funny for some time. The strip has had a lifelong mission statement to teach us about wildlife, but it's been giving us pet bears, deers, and raccoons, wildly miscolored birds, and plenty of bizarre misinformation.