What's your plan to get there? I-20 to Columbia and north I-26 to Spartanburg? If so, I would stop by the Kingsman in Cayce (a suburb of Columbia) for a truly good pimento cheeseburger, and hop off I-26 on US-176 to Union for really excellent BBQ, hash and rice and chicken mull at Midway BBQ. Both were mentioned by John T. Edge in the famous Garden & Gun "100 Southern Foods" article, and both can be found reported on my site (use the search our blog box in the link below).
US-176 will put you in Spartanburg near Sugar-n-Spice Drive-In, which I have not tried but would like to, or The Beacon, which everybody loves, and you can quickly reconnect with I-26 to continue north. I'm not familiar with anything along that way between S-burg and Asheville - yet - but Asheville is, of course, full of good eating: http://marieletseat.com/c...th-carolina-asheville/